第 筆
第 4 筆
國家圖書館索書號: 系統編號: 92NTU00442008
　　　　　出版年: 民93
　　　　　研究生: 郭玉誠 yu-cheng,kuo
(以研究生姓名查詢國家圖書館索書號 ，未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)　 (連結至政大圖書館館藏目錄)
　　　　電子全文: 電子全文下載
　　　　論文名稱: 血壓諧波變異係數於醫學工程之應用
　　　　論文名稱: Application of the Coefficient of Variation of the
Harmonic Magnitude (HCV) of the Arterial Pulse in Medical
Engineering
　　　　指導教授: 王唯工 wei-kung,wang
　　　　學位類別: 博士
　　　　校院名稱: 國立臺灣大學
　　　　系所名稱: 電機工程學研究所
　　　　　　學號: D86921034
　　　　　學年度: 92
　　　　　語文別: 中文
　　　　論文頁數: 112
　　　　　關鍵字: 血壓諧波變異係數 coefficient of harmonic
variation of magnitude
諧波穩定性 harmonic stability
系統崩潰 system failure
多重器官病變與衰竭 multi-organ disorder or
failure
死亡過程 dying process
[摘要]
當代高居十大死亡病因的重大疾病發展至疾病後期，均會發生多重器官病變與衰竭之系統
性影響。若以醫學工程的角度而言，系統崩潰是這些疾病共同的致病機轉與結果。
醫學工程以系統的觀點，運用各工程領域知識，透過定量生理分析與儀器設計，以解決臨
床上的問題。因此設計了動物與臨床兩個瀕死實驗，並且發現血壓諧波變異係數於死亡過
程中從高頻逐漸增加再一一擴及往低頻逐漸增加，逐步喪失諧波穩定性。證明血壓諧波變
異係數可以作為死亡過程中，系統崩潰的定量生理指標。並且透過非侵入性儀器的設計與
評估，驗證血壓諧波變異係數應用於新醫療儀器開發的評估指標可能性。
血壓諧波變異係數在不同階段疾病與死亡過程呈現出系統化的定量變化，使傳統醫學由脈
學診斷建立的系統觀得以確定；並提供中西醫學整合的平臺；更為重大疾病的防治指引新
方向。


[摘要]
The top ten mortality causes in twenty-one century, nearly all lead to
systemic multi-organ disorder or failure in the last stage. In the point view
of medical engineering, system failure is the general mechanism and ending of
these causes.
Thought the quantitatively physiological analysis and medical device design,
medical engineering utilizes systemic thinking and engineer knowledge to solve
the clinical problems；therefore, we designed animal and clinic experiments to
evaluate the coefficient of harmonic variation of magnitude (HCVs) and found
that all the harmonic components gradually lost their stability during dying
process. The HCVs, which increased first for the high-frequency components and
then the low-frequency components, could quantitatively reflect the process of
system failure. Meanwhile, through the design and evaluation of a noninvasive
device, we proved the HCVs’ ability applied to the new medical device
development.
The HCVs，which systematically and quantitatively indicates the severity of
different stages of illness and dying process，confirms the Chinese medical
system established from pulse diagnosis and provides the fundamental to the
integration of medicine；moreover, could indicate a new way to cure the top
ten mortality diseases in our time.


[論文目次]
目錄:
中文摘要
英文摘要
第一章:緒論　　　　　　　　　　　　　　　　　 1
第二章:血壓諧波變異係數與徑向共振理論　　　　18
第三章:血壓諧波變異係數於動物實驗之定量生理分析研究　　　　　　　　　　　　　　
28
第四章:血壓諧波變異係數於臨床之定量生理分析研究與應用　　　　　　　　　　　　　
57
第五章:血壓諧波變異係數於醫療儀器開發之應用　73
第六章:血壓諧波變異係數於傳統醫學科學化與醫學工程之應用　　　　　　　　　　　　
91
第七章:討論與未來展望　　　　　　　　　　　　97
參考資料　　　　　　　　　　　　　　　　　　102
第一章: 緒論
1-1多器官病變之系統疾病的威脅
1-2循環系統的重要性
1- 3西方醫學在循環系統上的瓶頸
1-4 傳統醫學的整體系統觀
1-5 以循環系統為核心的傳統醫學
第二章: 血壓諧波變異係數與徑向共振理論
2-1徑向共振理論為核心的系統觀
2-2徑向共振理論於臨床醫學上的應用
2- 3血壓諧波變異係數的定義
2-4血壓諧波變異係數的生理意義
第三章:血壓諧波變異係數於動物實驗之定量生理分析研究
3-1 實驗設計與實驗方法
3-2 實驗結果
3-3 實驗分析與討論
3-4 血壓諧波變異係數與心跳變異率之比較
第四章:血壓諧波變異係數於臨床之定量生理分析研究與應用
4-1 實驗設計與實驗方法
4-2 實驗結果
4-3 實驗分析與討論
4-3 血壓諧波變異係數於臨床之應用
第五章:血壓諧波變異係數於醫療儀器開發之應用
5-1非侵入式左心室輔助器之設計
5-2非侵入式左心室輔助器之生理評估
5-3非侵入式左心室輔助器之改進與再評估
5-4臨床實驗分析與討論
第六章:血壓諧波變異係數於傳統醫學科學化與醫學工程之應用
6-1血壓諧波變異係數與傳統醫學診斷之定量
6-2傳統醫學科學化之研究與醫學工程之建構
6-3傳統醫學科學化與創新研究
第七章:討論與未來展望
7-1血壓諧波變異係數與臨床醫學之系統整合
7-2血壓諧波變異係數與中西醫學整合
7-3血壓諧波變異係數的未來研究計畫


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